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1994-08-20
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Document 0449
DOCN M9480449
TI Tuberculosis and HIV infection in children in Abidjan, Cote d'Ivoire.
DT 9410
AU Sassan-Morokro M; De Cock KM; Ackah A; Vetter KM; Doorly R; Brattegaard
K; Coulibaly D; Coulibaly IM; Gayle H; Projet RETRO-CI, Abidjan, Cote
d'Ivoire.
SO Trans R Soc Trop Med Hyg. 1994 Mar-Apr;88(2):178-81. Unique Identifier :
AIDSLINE MED/94310627
AB Of 5180 consecutive outpatients diagnosed with tuberculosis in Abidjan,
Cote d'Ivoire (West Africa), between July 1989 and December 1990, 289
(6%) were children aged less than 15 years. The overall prevalence of
human immunodeficiency virus (HIV) 1 and/or HIV-2 infection in children
with tuberculosis was 11.8% (HIV-1, 10.0%; HIV-2, 0.7%; reactivity to
both viruses, 1%). The highest overall age-specific prevalence was in
children aged 1-4 years (23.4%), significantly higher than the rate in
attenders at a well child clinic (0.5%) (odds ratio 58.2). Of children
with tuberculosis, 26% had sputum smear-positive disease (HIV
seroprevalence 2.7%), 20% extrapulmonary disease (HIV seroprevalence
5.2%), and 54% were categorized as having 'clinical tuberculosis' (HIV
seroprevalence 18.6%) based on clinical signs and chest X-ray
abnormalities with negative sputum smears. Clinical tuberculosis was
most frequent in seropositive children, irrespective of age, and in
younger seronegative children. Extrapulmonary tuberculosis was equally
distributed across age groups, and pulmonary tuberculosis was
concentrated in older, seronegative children. HIV-positivity was
significantly associated with other features related to the acquired
immune deficiency syndrome such as wasting, chronic diarrhoea, oral
candidiasis, and negative tuberculin skin tests. Tuberculosis seems to
be associated with HIV infection in children in sub-Saharan Africa, but
better diagnostic techniques for paediatric tuberculosis are urgently
needed.
DE Acquired Immunodeficiency Syndrome/COMPLICATIONS/*EPIDEMIOLOGY
Adolescence Age Distribution Child Child, Preschool Cote
d'Ivoire/EPIDEMIOLOGY Human HIV Seroprevalence Infant Prevalence
Support, Non-U.S. Gov't Tuberculosis/COMPLICATIONS/*EPIDEMIOLOGY
Tuberculosis, Pulmonary/COMPLICATIONS/EPIDEMIOLOGY JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).